This led to the idea that factors influencing serum creatinine may differ between racial groups. Research from 1999 also observed that serum creatinine levels in Black participants were higher than in white participants with the same calculated GFR value. In 1998, before the development of common eGFR formulas, results from the National Health and Nutrition Examination Survey found that, on average, Black people had higher serum creatinine levels than people of other races. So, why exactly is race used to help determine eGFR? The answer to this question involves research observations that are now decades old. race, specifically whether or not you are Black.To determine eGFR, both of these formulas incorporate a variety of factors, including your: the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, developed in 2009.the Modification of Diet in Renal Disease (MDRD) formula, developed in 1999.Today, two of the most commonly used ones are: This can help them determine what types of treatment may be effective at slowing or halting its progression.Īs mentioned above, eGFR is calculated using a formula. The results of an eGFR calculation tell your doctor about the stage of your kidney disease. Doctors have also historically used race as a part of this formula as well. The formula to calculate eGFR uses the results of a serum creatinine test, but it also uses additional factors like your age, sex assigned at birth, and body size.
Because of this, creatinine levels in the blood are higher. However, kidneys that aren’t functioning well don’t filter creatinine into the urine efficiently. Kidneys that are functioning well filter creatinine from the blood and into the urine, where it’s eventually expelled from the body. The result of a blood test for creatinine, a waste product made by your muscles, is used to calculate eGFR. Lower scores are associated with lower levels of kidney function. EGFR is an estimation of how well your kidneys are working to filter your blood.
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